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Verywell / Andrea Hickey Nearly all antidepressants have the potential side effect of causing weight gain — 1 including Celexa (citalopram), a selective serotonin reuptake inhibitor (SSRI) similar to Prozac (fluoxetine) or Zoloft (sertraline) Hi all. Selegiline (Emsam), a newer MAOI that you apply to your skin, which may lead to fewer side effects than MAOIs taken by mouth Weight gain is also less likely to occur with the following SSRIs when. For about 3-4 months I have gained 40 lbs. I have been reading forums and articles, and a lot of them said that Citalopram causes a lot of weight gain. Because newer drugs tend to have fewer side effects, those two aren’t prescribed as frequently Over the course of 24 weeks, the researchers found that Lybalvi had similar effectiveness while causing significantly less weight gain and smaller increases in waist size compared with olanzapine. Two others that also appeared to have less weight gain were amitriptyline and nortriptyline. I thought I was the only one experiencing this. Side effects such as insomnia, drowsiness, dry mouth, nausea, and increased sweating may more Prescription only. In a 2014 study of more than 22,000 patient records, amitriptyline, bupropion (Wellbutrin SR, Wellbutrin XL), and nortriptyline (Pamelor) caused less weight gain than citalopram over the course of. I am a recently diagnosed Type 1 diabetic, and the insulin therapy already makes it tough to keep my weight stable. Bupropion was associated with the least amount of weight gain, close to none. I am very active and I eat very well, but I am concerned that the Citalopram will cause me to gain a lot of weight So many of the prescriptions cause weight gain but another reason is because they cause the person to get a larger appetite. Amitriptyline and nortriptyline are older drugs. 40 pounds later I finally realized it. Other antidepressants that appear less likely to have weight gain as a side effect include: Cymbalta (duloxetine) Effexor (venlafaxine) Lexapro (escitalopram) Pristiq (desvenlafaxine) Trintellix (vortioxetine) An antidepressant that works well for one person may not be as effective for another. The same can be said for side effects A large proportion of patients treated with paroxetine, mirtazapine, and other antidepressants, such as venlafaxine (EFFEXOR®, EFFEXOR XR®), gain a significant amount of weight.

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